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373 Results found Showing results 136-150 out of 373
  • Regular

    Mapping of stress-associated condensates across cellular and molecular scales in health and in ALS

    Prof. Hornstein Eran Weizmann Institute of Science Israel

    Dr. Shalem Ophir Children`s Hospital of Philadelphia USA

    Area of Research: Life Science - Cell and Developmental Biology | Cellular Substructures
    Keywords: RNA-binding protein, condensates, proximity labelling, mass spectrometry, in-situ sequencing, neurodegeneration, amyotrophic lateral sclerosis
    2021 | 2021181 | $213000
    Lay Abstract
  • Regular

    Biological pathways regulating gamete quality during the pubertal transition

    Dr. Klutstein Michael The Hebrew University Israel

    Dr. Duncan Francesca Northwestern University, Chicago Campus USA

    Dr. Imbar Tal Hadassah Medical Organization Israel

    Area of Research: Medicine | Medicine - Child and Human Health, Human Development, Fertility
    Keywords: oocytes, ovary, puberty, cancer, fertility, fertility preservation, meiosis, hormones
    2021 | 2021180 | $213000
    Lay Abstract
  • Regular

    The evolutionary role of sleep in regulating DNA repair

    Prof. Appelbaum Lior Bar Ilan University Israel

    Prof. Keene Alex Texas A&M University USA

    Area of Research: Life Science - Animal Sciences | Behavior, Adaptation and Evolution
    Keywords: Sleep, Cavefish, Zebrafish, DNA repair
    2021 | 2021177 | $284000
    Lay Abstract
  • Regular

    Elucidating the spatiotemporal control of MRGPRX2 function

    Prof. Sagi-Eisenberg Ronit Tel Aviv University Israel

    Prof. Ali Hydar University of Pennsylvania USA

    Area of Research: Life Science - Immunology | Allergy
    Keywords: Mast cells, Mas related G protein coupled receptor X2, Degranulation, GPCR, Rab GTPases, pseudo-allergy
    2021 | 2021172 | $284000
    Lay Abstract
  • Regular

    Mechanistic studies of the regulation of osteoclast fusion by the osteopetrosis-associated proteins OSTM1 and SNX10

    Prof. Elson Ari Weizmann Institute of Science Israel

    Dr. Chernomordik Leonid National Inst of Child Hlth & Human Develop, NIH USA

    Prof. Geiger Benjamin Weizmann Institute of Science Israel

    Area of Research: Life Science - Cell and Developmental Biology | Cell Differentiation
    Keywords: osteoclast, osteopetrosis, SNX10, OSTM1, cell fusion
    2021 | 2021168 | $256000
    Lay Abstract
  • Startup

    Structural studies of hepatitis C virus E1E2 envelope proteins to facilitate the development of a hepatitis C vaccine

    Dr. TZARUM NETANEL The Hebrew University Israel

    Prof. Law Mansun Scripps Research Institute USA

    Area of Research: Life Science - Biochemistry | Structural Biology
    Keywords: Hepatitis C Virus (HCV), Broadly neutralizing antibodies(bnAbs), X-ray crystallography, Vaccine design, Heavy chain antibodies
    2021 | 2021165 | $75000
    Lay Abstract
  • Regular

    Decoding the molecular basis of human kidney development at single cell resolution: a novel personalized approach for congenital kidney anomalies

    Dr. Pleniceanu Oren Medical Research Fund - Sheba Medical Center Israel

    Prof. Susztak Katalin University of Pennsylvania USA

    Area of Research: Medicine - Metabolic and Endocrine Systems | Nephrology & Urology
    Keywords: Nephrology, kidney development, nephrogenesis, epigenetics, chromatin accessibility, single cell rna-seq, ATAC-seq, congenital anomalies of the kidney and urinary tract, regulatory elemtents
    2021 | 2021164 | $284000
    Lay Abstract
  • Regular

    Do B cells promote dementia in Down Syndrome?

    Prof. Okun Eitan Bar Ilan University Israel

    Dr. Biragyn Arya NIH-National Institute of Aging USA

    Area of Research: Medicine - Neurological and Sensory Systems | Neurodegenerative Diseases
    Keywords: adaptive immunity, b cells, Alzheimer`s disease, Amyloid beta
    2021 | 2021163 | $198000
    Lay Abstract
  • Regular

    Biosynthesis of Styrene and its Analogs in Styrax officinalis L.

    Dr. Ibdah Mwafaq Agricultural Research Organization Israel

    Prof. Doudareva Natalia Purdue University USA

    Area of Research: Life Sciences | Life Science - Biochemistry
    Keywords: Styrene, Styrax, 2-Phenylethanol
    2021 | 2021157 | $213000
    Lay Abstract
  • Regular

    The cell-type-specific roles of ventral pallidum neurons in fentanyl abstinence

    Dr. Kupchik Yonatan The Hebrew University Israel

    Dr. Lobo Mary Kay University of Maryland, Baltimore USA

    Area of Research: Life Science - Neurobiology | Circuits, Neuronal Populations
    Keywords: Addiction, Ventral pallidum, Nucleus accumbens, fentanyl, electrophysiology, single-cell RNA sequencing, synaptic physiology, chemogenetics, DREADDs
    2021 | 2021154 | $284000
    Lay Abstract
  • Regular

    Cell extrinsic Polycomb-mediated epigenetic signaling in Melanoma

    Dr. Cohen Idan Ben Gurion University Israel

    Dr. Ezhkova Elena Icahn School of Medicine at Mount Sinai USA

    Area of Research: Medicine - Cancer | Genetics
    Keywords: Polycomb, PRC2, H3K27me3, Epidermis, Epidermal stem cells, Melanocytes, Melanoma, Epigenetics
    2021 | 2021147 | $284000
    Lay Abstract
  • Regular

    Mathematical modeling of Genome Architecture Evolution in Prokaryotes

    Prof. Snir Sagi The University of Haifa Israel

    Prof. Koonin Eugene National Library of Medicine USA

    Area of Research: Life Science - Molecular Biology and Genomic Research | Molecular Evolution
    Keywords: Horizontal Gene Transfer, Genome Dynamics, Gene String Conservation, Phylogenetics
    2021 | 2021139 | $198000
    Lay Abstract
  • Regular

    Targeting inflammasome activation by titanium particles as a pathogenic mechanism inducing non-resolving bacteria-related peri-implant bone loss

    Dr. Weinberg Evgeny Tel Aviv University Israel

    Prof. Gabet Yankel Tel Aviv University Israel

    Dr. Kotsakis Georgios Rutgers University USA

    Area of Research: Medicine | Medicine - Infectious & Immunological diseases (Inc. Allergy and autoimmunity)
    Keywords: Peri-implantitis, NLRP3 inflammasome, IL1b, Titanium particles, Oral bacteria
    2021 | 2021138 | $272000
    Lay Abstract
  • Regular

    Novel mechanism of drug resistance in cancer cells

    Prof. Sherman Michael Ariel University Israel

    Prof. Mirny Leonid Massachusetts Institute of Technology USA

    Area of Research: Life Science - Genetics, Bioinformatics and Computational Biology | Functional Genomics
    Keywords: drug resistance, irinotecan, DNA breaks, DNA repair
    2021 | 2021137 | $198000
    Lay Abstract
  • Regular

    Characterizing Epigenetic Regulators of Virulence and Lifestyle Shifts in an Entomopathogenic Fungus

    Dr. Ment Dana Agricultural Research Organization Israel

    Dr. Granek Joshua Duke University - Medical Ctr USA

    Area of Research: Life Science - Microbiology | Pathogenic Mycology
    Keywords: Epigenetics, DNA Methylation, Fungal Pathogen, Single- Molecule Sequencing, Bioinformatics, Transcriptome, Entomopathogenic Fungi, Host-pathogen Interaction, Saprophytic development
    2021 | 2021135 | $204000
    Lay Abstract